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SUMMARY:Targeting liver mitochondria to treat MASLD/MASH and cardiometabol
 ic disease - Professor Gerald Shulman
DTSTART:20240320T150000Z
DTEND:20240320T160000Z
UID:TALK213046@talks.cam.ac.uk
CONTACT:Lisa Arnold
DESCRIPTION:Insulin resistance is a critical factor in the pathogenesis of
  type 2 diabetes. In addition insulin resistance plays a key role in the p
 athogenesis of MASLD/MASH\, heart disease\, obesity-associated cancers and
  Alzheimer’s disease. In this lecture I will review recent studies that 
 have demonstrated the safety and efficacy of liver-targeted mitochondrial 
 uncoupling agents to treat these diseases in both animal models and humans
  with MASLD/MASH and cardiometabolic disease. I will also review some nove
 l 13C NMR and LC-MS/MS methods (PINTA and Q-Flux) that we have recently de
 veloped to assess rates of hepatic mitochondrial oxidation and anaplerotic
  fluxes in vivo.
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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