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SUMMARY:LMB Seminar: Super-resolution imaging of transcription in living c
 ells - Ibrahim Cissé\, Department of Biological Physics\, Max Planck Inst
 itute of Immunobiology and Epigenetics\, Freiburg\, Germany
DTSTART:20240411T100000Z
DTEND:20240411T110000Z
UID:TALK213052@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:We will discuss the latest efforts in our laboratory to develo
 p highly sensitive methods of microscopy\, to go directly inside living ce
 lls and uncover the behavior of single biomolecules as they effect their f
 unction in transcription. Transcription is the first step in gene expressi
 on regulation\, during which genetic information on DNA is decoded into RN
 A transcripts. Methodologically\, the so-called live cell single molecule 
 and super-resolution techniques – that break the optical diffraction lim
 it– are revealing with unprecedented spatial and temporal resolutions\, 
 novel emergent phenomena inside the living cells. We will discuss our rece
 nt discoveries on highly dynamic biomolecular clustering\, and phase trans
 itions in vivo. These discoveries are challenging the ‘textbook view’ 
 on how our genome (DNA) is decoded in living cells.
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m\, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/99208619370?pwd=MkR4anNjVFht
 bHlIQmRSZzBobWxNdz09
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