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SUMMARY:LMB Seminar: Evading ageing: Mitochondrial and proteostatic adapta
 tions in oocytes  - Elvan Boke\,  Group Leader\, Centre for Genomic Regula
 tion (CRG)\, Barcelona\, Spain 
DTSTART:20240507T150000Z
DTEND:20240507T160000Z
UID:TALK213061@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Oocytes are female germ cells that become eggs. They have the 
 remarkable ability to survive for long periods of time\, up to 50 years in
  humans\, while retaining the ability to give rise to a new organism. We k
 now surprisingly little about the molecular mechanisms through which oocyt
 es alleviate cellular ageing\, and why such mechanisms eventually fail wit
 h advanced age. In this talk\, I will discuss two recent discoveries that 
 address two issues that oocytes face during their long life. I will illust
 rate how oocytes limit damage by Reactive Oxygen Species (ROS)  by dispens
 ing with mitochondrial complex I.  I will also illustrate how oocytes deal
  with protein aggregation by sequestering aggregates in large non-membrane
 -bound compartments that we named Endo-Lysosomal Vesicular Assemblies (ELV
 As).  These discoveries demonstrate the range of distinct adaptations of o
 ocyte metabolism and proteome to accommodate the long oocyte lifespan.
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m\, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/92134536179?pwd=bHVnRkpmamhn
 WWY2bXpVMHAyblhlZz09
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