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SUMMARY:Modelling and Targeting the Tumour Microenvironment of High-Grade 
 Serous Ovarian Cancer - Professor Frances Balkwill OBE\, FMedSci\, Centre 
 for Tumour Microenvironment\, Barts Cancer Institute\, Queen Mary Universi
 ty of London\, UK
DTSTART:20240503T120000Z
DTEND:20240503T130000Z
UID:TALK213163@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:We have developed a platform of models of the tumour microenvi
 ronment (TME) of high-grade serous ovarian cancer (TME) with the aim of im
 proving our understanding of TME regulation and testing new biological the
 rapies. We began with a multi-omic ‘deconstruction’ of the human TME w
 hich we use as a template and validation for our work. Three areas of curr
 ent interest that will be presented are as follows:\n1.	We have developed 
 penta-culture (five cell) human cell HGSOC models to study malignant cell 
 regulation of myeloid cell differentiation and test therapies that target 
 tumour-associated macrophages. \n2.	We are investigating how malignant cel
 ls and fibroblasts modulate CAR-T cell activity in human 3D in vitro cell 
 models of increasing complexity. These include microfluidic models where w
 e deliver CAR-T cells through vasculature in a cancer-on-a-chip model.\n3.
 	Using a combination of human and mouse data\, and mouse HGSOC models that
  replicate the human TME\, we are studying the role of the extracellular m
 atrix in resistance to chemotherapy.\n\n
LOCATION:CRUK CI Lecture Theatre
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