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SUMMARY:How use of SSRI impacts placenta and mammary gland development - L
 aura L. Hernandez\, Department of Animal and Dairy Sciences  University of
  Wisconsin-Madison
DTSTART:20240515T150000Z
DTEND:20240515T160000Z
UID:TALK213178@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Selective serotonin reuptake inhibitors (SSRI) are the most co
 mmonly prescribed drug class in the US. \nUntreated depression during preg
 nancy creates a risk for maternal wellbeing and is coupled with adverse pr
 egnancy outcomes with causes that are poorly understood and use of SSRI am
 ong pregnant women is increasing. Fluoxetine (Prozac) and sertraline (Z
 oloft) are the most prescribed medications for pregnant women in their 
 first trimester. With nearly one in five women experiencing depression\, S
 SRI use during pregnancy continues to increase in the US. Antenatal SSRI u
 se has been demonstrated to also result in increased neonatal mortality an
 d morbidity. Therefore\, presenting a conundrum for medical care providers
  when making decisions as to how to treat pregnant women with depression a
 nd also protect the pregnancy\, and health outcomes for the infant. Import
 antly\, and often under looked\, is that SSRI not only impact the neuronal
  serotonin transporter (SERT)\, but they also impact the effects of SERT t
 hroughout the body. Our work has recently demonstrated that treatment with
  fluoxetine prepartum results increased death of offspring and increased m
 orbidity for the offspring that survive\, which we have recapitulated in a
  sheep model. Further\, our work demonstrates the SSRI also impact both ma
 mmary gland function and development\, as well as maternal outcomes\, rece
 ntly demonstrating that use of fluoxetine increases adiposity in offspring
  up to 12 weeks of age\, and that male offspring appear to be disproportio
 nally affected. We continue to investigate the impact of SSRI use on the p
 lacenta\, mammary gland development\, and long-term effects on both dam an
 d offspring. Our goal is to develop novel interventions that will allow th
 e dam to continue SSRI treatment if needed that will not impact her long-t
 erm health\, as well as the long-term health of the offspring.\n
LOCATION:by zoom
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