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SUMMARY:Babraham Distinguished Seminar - Lipid switches in cell physiology
 : From nutrient signals to disease - Prof Volker Haucke\; Leibniz Forschun
 gsinstitut für Molekulare Pharmakologie (FMP)
DTSTART:20240328T130000Z
DTEND:20240328T143000Z
UID:TALK213196@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Following his PhD in biochemistry from the Biozentrum of the U
 niversity of Basel and postdoctoral work at Yale University School of Medi
 cine Volker Haucke established his own laboratory at the University of Gö
 ttingen. He was appointed as a full professor of biochemistry at the Freie
  Universiät Berlin in 2003. Since 2012 he is director at the Leibniz Fors
 chungsinstitut für Molekulare Pharmakologie (FMP)\, professor of molecula
 r pharmacology at Freie Universität Berlin and a member of the NeuroCure 
 Cluster of Excellence. The focus of research in his laboratory is the diss
 ection of the molecular mechanisms of endocytosis and endolysosomal membra
 ne dynamics with a focus on the role of signaling lipids. The laboratory u
 ses a wide range of technologies that include biochemical and cell biologi
 cal approaches\, electrophysiology\, chemical biology\, super-resolution a
 nd electron microscopy as well as genetic manipulations at the organismic 
 level in vivo. His discoveries have provided insight into the roles of lip
 ids in cell physiology and open new avenues for the treatment of human dis
 eases ranging from cancer and thrombosis to neurological disorders.\n\nPho
 sphoinositides (PIs) form a minor class of phospholipids with crucial func
 tions in cell physiology\, ranging from cell signalling and motility to a 
 role as signposts of compartmental membrane identity and dynamics. In fed 
 cells\, phosphatidylinositol 3-phosphates are present at the plasma membra
 ne and within the endosomal system\, where they serve as key regulators of
  both cell signaling and of intracellular membrane dynamics\, while PI 4-p
 hosphates delineate the secretory pathway. In my talk I will discuss the l
 ocalization\, regulation\, and molecular mechanism of action of PI kinases
  and phosphatases and their roles in endocytosis and within the endolysoso
 mal system. Moreover\, I will cover our recent advances in the analysis of
  the metabolic pathways that regulate the cellular synthesis and turnover 
 of distinct PI phosphates at endosomes or lysosomes in response to alterin
 g nutrient conditions\, discuss the mechanisms by which these lipids regul
 ate endolysosomal membrane dynamics and metabolism\, and provide examples 
 of how dysregulation of these pathways may cause human disease. Our data p
 rovide a framework for how PI phosphate metabolism is integrated into the 
 cellular network and identify PI kinases as targets for future therapeutic
 s.\n\nRegistration is required - https://www.eventbrite.co.uk/e/babraham-d
 istinguished-lecture-prof-volker-haucke-tickets-796846568537\n
LOCATION:Petersfield Lecture Theatre\, Babraham Research Campus
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