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SUMMARY:The ins and outs of mitochondrial protein quality control - Profes
 sor Dr Christian Münch
DTSTART:20240410T140000Z
DTEND:20240410T150000Z
UID:TALK213538@talks.cam.ac.uk
CONTACT:Lisa Arnold
DESCRIPTION:Balanced protein homeostasis (proteostasis) in the different c
 ellular compartments is crucial to maintain function and survival. Proteos
 tasis processes involve controlling protein folding\, processing\, and deg
 radation. In mitochondria\, protein import adds further complexity to prot
 eostasis. Therefore\, it is necessary to regulate both intra- and extra-mi
 tochondrial processes to adjust mitochondrial proteostasis to varying cond
 itions.\nThe presentation will focus on our recent results that examine th
 e interplay of protein quality control mechanisms across compartments. I w
 ill present data on the consequences of mitochondrial protein misfolding a
 nd the subsequent retrograde signaling via the mitochondrial unfolded prot
 ein response\, adjustments in mitochondrial protein translation and import
 \, and degradation of mitochondria by mitophagy. These processes are tight
 ly integrated to ensure mitochondrial proteostasis. Furthermore\, I will p
 resent new data on the role of mitochondrial proteostasis in replicative s
 enescence. We found molecular links between perturbed stress signaling and
  mitochondrial dysfunction that act as key driver of senescence. \n
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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