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SUMMARY:Deadly competition between sibling bacterial colonies - Avraham Be
 'er\, CNLD\, University of Texas at Austin
DTSTART:20091105T130000Z
DTEND:20091105T140000Z
UID:TALK21378@talks.cam.ac.uk
CONTACT:Raymond E. Goldstein
DESCRIPTION:As a result of stress due to nutrient limitation or antibiotic
 s\, competing individual bacteria within a single colony may lyse sibling 
 cells to release nutrients (cannibalism) or DNA (fratricide). However\, we
  have recently shown that competition is not limited to individuals\, but 
 can occur at the colony level. In response to the presence of an encroachi
 ng sibling colony\, <i>Paenibacillus dendritiformis</i> bacteria secrete a
  lethal protein\, lysing cells at the interface between the colonies. Anal
 ysis of the proteins secreted by these competing sibling colonies\, combin
 ed with a mathematical model\, show how colonies maintain their growth by 
 self-regulating the secretion of two significant proteins: subtilisin (a g
 rowth promoter)\, and Slf (a lethal protein). The results also explain why
  a single colony is not inhibited by its own secretions.
LOCATION:MR15\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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