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SUMMARY:Understanding the Origins of Aggressive Cancers - Viji M. Draviam 
 (Department of Genetics\, University of Cambridge)
DTSTART:20091123T193000Z
DTEND:20091123T200000Z
UID:TALK21515@talks.cam.ac.uk
CONTACT:Shakir Mohamed
DESCRIPTION:How does a mother cell divide its chromosomes equally among it
 s two daughter cells? Lessons from yeasts to humans on understanding the o
 rigins of aggressive cancers. \n\nIn the lifetime of a human being\, billi
 ons of cells divide. Each of these cell division events has to be orchestr
 ated in a precise and error free manner\, to achieve the ultimate goal of 
 cell division - separating the mother cell's chromosomes into two equal se
 ts for the two daughter cells. We now know that this high-level of precisi
 on in chromosome segregation throughout life is achieved by a sensitive su
 rveillance mechanism that is shared among several life forms from yeasts t
 o humans. Any failure in the surveillance machinery will result in irregul
 ar number of chromosomes\, as often seen in aggressive cancer cells. Using
  live-cell movies\, the talk will highlight the molecular players that are
  critical for the success of the robust surveillance mechanism and will op
 en the floor to discuss about tools that can be designed to help diagnosis
  and treatment of cancers.\n\nThe short talk will try to reach out to a wi
 de audience interested in cancer biology\, cutting-edge microscopy techniq
 ues\, associated computational challenges\, complex molecular machines\, e
 volutionarily conserved regulation\, or simply watching movies of human ce
 lls undergoing division.\n
LOCATION:Old Music Room (A First Court)\, St John's College
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