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SUMMARY:Mechanisms and mechanics of morphogenesis - Katja Röper\, Univers
 ity of Cambridge
DTSTART:20240513T133000Z
DTEND:20240513T143000Z
UID:TALK215905@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Abstract: \n\nHow organ shape and therefore function is encode
 d by the genome remains a major unresolved question in biology. All tissue
 s arise from simple precursors or primordia. These become patterned throug
 h transcriptional changes within individual cells\, and we have made much 
 progress in untangling gene regulatory networks responsible\, especially m
 ore recently using single-cell genome-wide approaches. How such patterning
  is then turned into physical changes at the molecular\, cell and tissue s
 cale is much less understood. This is the focus of my lab’s research\, t
 he emergence of shape and function\, primed by cell-specific transcription
 al changes\, but implemented through highly coordinated changes of many ce
 lls in conjunction. Although transcriptional and biochemical control opera
 tes in individual cells\, coordination works at the tissue scale\, and we 
 so far only understand small aspects of it. Because organ shape is critica
 l for organ function\, defects in morphogenesis lead to severe diseases in
 cluding spina bifida or polycystic kidney disease. We want to understand t
 he importance of cytoskeletal crosstalk\, the coordination of events and f
 orces within a tissue\, and the role of spatial and temporal control by up
 stream transcriptional regulation. To do so\, we utilise a highly tractabl
 e model process in Drosophila and combine it with a powerful organoid cult
 ure models of human tissue morphogenesis. \n\nZoom link:  https://cam-ac-u
 k.zoom.us/j/87939943699 (Meeting ID: 879 3994 3699)
LOCATION:In person at Bryan Matthews Room\, PDN and online
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