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SUMMARY:You are not encoded - a biological theory of form - Alan Rodrigues
 \, Rockefeller University
DTSTART:20240520T133000Z
DTEND:20240520T143000Z
UID:TALK215908@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Presenter: Alan Rodrigues (Co-director\, The Laboratory of Mor
 phogenesis\, Rockefeller University)\n\nAbstract: In recent decades\, much
  progress has been made in understanding how genes within cells contribute
  to organ-specific fates or disease phenotypes. However\, it is becoming m
 ore widely acknowledged that increasing understanding at the molecular sca
 le has not been sufficient to fully grasp how tissues comprised of thousan
 ds of cells generate their structures. To address this gap\, the Shyer/Rod
 rigues lab centers its studies on the behavior of cell collectives in vert
 ebrate tissues. Using novel collective cell behavioral assays and the skin
  as a model\, we find that emergent biophysical properties arise at the 
 ‘supra’-cellular scale during organ development. Such emergent propert
 ies then serve to shape the skin. Our findings indicate that epigenetic pr
 ocesses beyond the cell scale can organize morphogenesis in vertebrate tis
 sues. Finally\, uncovering such epigenetic processes has allowed us to pro
 vide an account of morphogen function that re-envisions canonically accept
 ed roles of these chemical cues.\n\nZoom link: \nJoin Zoom Meeting\nhttps:
 //cam-ac-uk.zoom.us/j/87939943699  Meeting ID: 879 3994 3699 
LOCATION:Online
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