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SUMMARY:Multiscale mechanical linkage elongates tissues in development - S
 hinuo Weng\, Johns Hopkins University
DTSTART:20240528T133000Z
DTEND:20240528T143000Z
UID:TALK215917@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Cells and tissues acquire their shape and function during embr
 yonic development.  While the blueprint for tissue design is encoded in th
 e genome\, the execution of this program relies on the mechanical progress
 ion of coordinated behaviors at molecular\, cellular\, and tissue scales. 
  Thus\, understanding the emergence of biomechanical features and their fu
 nctions in morphogenesis across multiple scales is fundamental to elucidat
 ing normal development and the mechanisms underlying congenital malformati
 on. \n\nMy research has focused on convergent extension (CE)\, a conserved
  collective cell movement that elongates the head-to-tail body axis and se
 veral organ systems\, including the neural tube\, heart\, and kidney.  Rec
 ent studies have identified novel biomechanical features across multiple s
 cales crucial to CE.  Our data suggest that cellular forces propagate in a
  polarized manner\, driving the propagation of coordinated cell movement. 
  This multiscale mechanical linkage generates a synergistic effect\, promo
 ting efficient and robust body axis elongation.  Conversely\, subtle biome
 chanical compromises at the subcellular level can escalate over time and s
 pace\, ultimately leading to axis elongation failure in the entire organis
 m. \n\nonline %{color:red}TUESDAY%\n\nZoom link: Join Zoom Meeting https:/
 /cam-ac-uk.zoom.us/j/87939943699 Meeting ID: 879 3994 3699
LOCATION:online TUESDAY
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