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SUMMARY:Non-uniform regulation of epigenetic marks via metabolism in a dev
 eloping tissue - Professor Dr Aurelio Teleman
DTSTART:20240508T140000Z
DTEND:20240508T150000Z
UID:TALK216160@talks.cam.ac.uk
CONTACT:Lisa Arnold
DESCRIPTION:Histone acetylation regulates gene expression\, cell function\
 , and cell fate. We studied the pattern of histone acetylation in an epith
 elial tissue\, the Drosophila wing disc and find that H3K18ac\, H4K8ac\, a
 nd total lysine acetylation are elevated in the outer rim of the disc. Thi
 s is due in part to high fatty acid β-oxidation (FABO) in the rim\, and p
 artly due to nuclear positioning. This affects gene expression. In sum\, t
 here is a physical mark of the outer rim of the wing and other epithelia i
 n Drosophila.
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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