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SUMMARY:Structural disorder of proteins in vitro and in vivo - Prof. Peter
  Tompa\, Institute of Enzymology\, Hungarian Academy of sciences
DTSTART:20091124T110000Z
DTEND:20091124T120000Z
UID:TALK21621@talks.cam.ac.uk
CONTACT:M. Madan Babu
DESCRIPTION:Intrinsically disordered proteins (IDPs/IUPs) exist and functi
 on without a well-defined 3D structure\, defying the classical structure-f
 unction paradigm [1]. Structural disorder is widespread in eukaryotic prot
 eomes and correlates with important functions such as signal transduction 
 and transcription regulation. Whereas currently increasing effort is focus
 ed on these proteins\, most of our concepts regarding their structure and 
 function stem from in vitro data. In my talk I will briefly overview the f
 ield of structural disorder\, with a major focus on the special functional
  modes it enables\, and also touch upon evidence for their existence in vi
 vo. I will show how bioinformatics tools can be used to address important 
 issues with respect to their physiological existence\, function and regula
 tion. Overall\, the message of my talk is that despite much controversy ab
 out the physiological importance of these proteins\, the evidence is overw
 helming that their unusual structural state is a highly evolved feature en
 abling exciting biology in the cell.\n\n1. Tompa\, P. (2009) Structure and
  Function of Intrinsically Disordered Proteins. CRC Press\n
LOCATION:Max Perutz Lecture Theatre\, MRC Laboratory of Molecular Biology\
 , Cambridge\, UK
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