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SUMMARY:Network origins of the brain’s synergistic informational archite
 cture - Andrea Luppi\, University of Cambridge
DTSTART:20240510T130000Z
DTEND:20240510T140000Z
UID:TALK216562@talks.cam.ac.uk
CONTACT:113437
DESCRIPTION:How does the organization of neural information processing ena
 ble humans’ sophisticated cognition? Here we decompose functional intera
 ctions between brain regions into synergistic and redundant components\, r
 evealing their distinct information-processing roles. Combining functional
  and structural neuroimaging with meta-analytic results\, we demonstrate t
 hat redundant interactions are predominantly associated with structurally 
 coupled\, modular sensorimotor processing. Synergistic interactions instea
 d support integrative processes and complex cognition across higher-order 
 brain networks. The human brain leverages synergistic information to a gre
 ater extent than nonhuman primates\, with high-synergy association cortice
 s exhibiting the highest degree of evolutionary cortical expansion. Synapt
 ic density mapping from positron emission tomography and convergent molecu
 lar and metabolic evidence demonstrate that synergistic interactions are s
 upported by receptor diversity and human-accelerated genes underpinning sy
 naptic function. This information-resolved approach provides analytic tool
 s to disentangle information integration from coupling\, enabling richer\,
  more accurate interpretations of functional connectivity\, and illuminati
 ng how the human neurocognitive architecture navigates the trade-off betwe
 en robustness and integration.\n\n\nPre-reading:\n\n1. "Luppi et al 2022 N
 ature Neuroscience":https://www.nature.com/articles/s41593-022-01070-0 \n\
 n2. "Mediano\, Rosas et al 2021 arXiv":https://arxiv.org/abs/2109.13186\n
LOCATION:CUED Baker Building - CLIC 1 Meeting Rm
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