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SUMMARY:Mechanics of asymmetric cell division - Alexander Mietke\, Univers
 ity of Oxford
DTSTART:20240620T120000Z
DTEND:20240620T130000Z
UID:TALK216775@talks.cam.ac.uk
CONTACT:Marco Vona
DESCRIPTION:The control of cell shape during cytokinesis requires a precis
 e regulation of mechanical properties of the cell cortex. Only few studies
  have addressed the mechanisms underlying the robust production of unequal
 -sized daughters during asymmetric cell division and\, in particular\, the
  mechanisms that ensure cell division is a mechanically stable process. In
  particular\, Laplace pressure gradients inside the dividing cell generall
 y tend to destabilize the cell surface\, an effect that will be even more 
 pronounced when cells divide in an asymmetric fashion. Experiments with as
 ymmetrically dividing sensory organ precursor (SOP) cells in Drosophila sh
 ow that modifications of relative amounts of branched Actin in the two dau
 ghter cells during division are sufficient to engineer essentially arbitra
 ry daughter-size asymmetries. Following this observation\, we introduce a 
 minimal model of the division process that reveals cortical bending rigidi
 ty as a crucial ingredient to quantitatively explain both the observed siz
 e asymmetries in SOP daughter cells\, as well as the mechanical stability 
 of the underlying division process.
LOCATION:MR14\,  Centre for Mathematical Sciences\, Wilberforce Road\, Cam
 bridge
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