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SUMMARY:Systematic design and control of biochemical reaction networks - T
 omislav Plesa\, University of Cambridge
DTSTART:20240530T120000Z
DTEND:20240530T130000Z
UID:TALK216778@talks.cam.ac.uk
CONTACT:Lloyd Fung
DESCRIPTION:Many questions in biology can be formulated as a direct proble
 m: Given a biochemical system\, can one deduce some of its properties? How
 ever\, in the field of synthetic biology and DNA computing\, the central p
 roblem is an inverse one: Given a property\, can one design a biochemical 
 system that displays this property? Given a biochemical system\, can one i
 ntroduce additional molecular species to control properties of the origina
 l system? In this talk\, I will present mathematical methods for systemati
 c design and control of biochemical systems using two modelling approaches
 :\n(i) less-detailed deterministic models\, taking form of ordinary differ
 ential equations for concentrations of molecular species\, and \n(ii) more
 -detailed stochastic models\, taking form of the Gillespie stochastic simu
 lation algorithm for copy-numbers of molecular species.\nI will demonstrat
 e the mathematical methods by constructing relatively simple biochemical s
 ystems displaying exotic dynamics\, such as multi-stability\, oscillations
 \, chaos\, specific bifurcation structures\nand noise-induced phenomena. 
LOCATION:MR20\,  Centre for Mathematical Sciences\, Wilberforce Road\, Cam
 bridge
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