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SUMMARY:Understanding Mechanisms of Microenvironment-Mediated Therapy Resi
 stance - Professor Michael Hemann\, Koch Institute for Integrative Researc
 h at MIT
DTSTART:20241213T130000Z
DTEND:20241213T140000Z
UID:TALK217147@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Many human cancers fail to respond to DNA damaging chemotherap
 y\, and cancers that initially respond frequently acquire drug resistance 
 and relapse. This process of tumor relapse is particularly confounding\, a
 s patients can be in remission for years following treatment prior to the 
 reemergence of a cancer. Our group has used in vivo genetic screens  to sh
 ow that select microenvironments can underlie resistance to chemotherapy a
 nd cell-based immunotherapy and persistence of microenvironment-specific r
 esidual disease. Our findings highlight potential avenues for therapeutic 
 synergy by targeting pathways involved in context-dependent drug resistanc
 e.
LOCATION:CRUK CI Lecture Theatre
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