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SUMMARY:A neural mechanism for terminating decisions - Adam Triabhall
DTSTART:20240612T130000Z
DTEND:20240612T140000Z
UID:TALK217966@talks.cam.ac.uk
CONTACT:Adam Triabhall
DESCRIPTION:This week we will discuss and debate a very recent paper by St
 ine and colleagues\, published in Neuron (2023).\n\nAbstract: “The brain
  makes decisions by accumulating evidence until there is enough to stop an
 d choose. Neural\nmechanisms of evidence accumulation are established in a
 ssociation cortex\, but the site and mechanism\nof termination are unknown
 . Here\, we show that the superior colliculus (SC) plays a causal role in 
 terminating decisions\, and we provide evidence for a mechanism by which t
 his occurs. We recorded simultaneously from neurons in the lateral intrapa
 rietal area (LIP) and SC while monkeys made perceptual decisions. Despite 
 similar trial-averaged activity\, we found distinct single-trial dynamics 
 in the two areas:\nLIP displayed drift-diffusion dynamics and SC displayed
  bursting dynamics. We hypothesized that the\nbursts manifest a threshold 
 mechanism applied to signals represented in LIP to terminate the decision.
 \nConsistent with this hypothesis\, SC inactivation produced behavioral ef
 fects diagnostic of an impaired\nthreshold sensor and prolonged the buildu
 p of activity in LIP. The results reveal the transformation from\ndelibera
 tion to commitment” (Stine et al.\, 2023).\n\nReference: Stine\, G. M.\,
  Trautmann\, E. M.\, Jeurissen\, D.\, & Shadlen\, M. N. (2023). A neural m
 echanism for terminating decisions. Neuron\, 111(16)\, 2601-2613.
LOCATION:https://cam-ac-uk.zoom.us/j/92612577704?pwd=MUtqMjVQdXNmUTVIYjRkM
 G1NUW9GZz09
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