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SUMMARY:The role of NK cells and their receptors in cancer and transplanta
 tion - Professor Jeffrey Miller\, University of Minnesota
DTSTART:20100215T123000Z
DTEND:20100215T133000Z
UID:TALK21903@talks.cam.ac.uk
CONTACT:Prof. Jim Kaufman
DESCRIPTION:Dr. Miller's research team works in two areas that seek to und
 erstand fundamental issues regarding innate immune function: 1.) How undif
 ferentiated stem cells develop into functioning NK cell lymphocytes\, and 
 2.) How to manipulate NK cells to treat or prevent cancer relapse. Most of
  his work focuses on receptors on NK cells that recognize class I MHC mole
 cules. \n\nThe hypothesis underlying current research efforts is that "sel
 f" MHC molecules influence the NK cell receptor repertoire and NK cell edu
 cation during development. These NK cell receptors may also play a physiol
 ogic role in cancer. Clinical trials using allogeneic NK cells in acute le
 ukemia and solid tumors are underway. Recent transplantation studies have 
 identified the importance of certain killer-cell immunoglobulin-like recep
 tor (KIR) donor genes responsible for protection against acute myelogenous
  leukemia relapse. \n\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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