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SUMMARY:Controlling secretion at the immunological synapse - Professor Gil
 lian Griffiths\, CIMR\, University of Cambridge
DTSTART:20100310T123000Z
DTEND:20100310T133000Z
UID:TALK21907@talks.cam.ac.uk
CONTACT:Prof. Jim Kaufman
DESCRIPTION:Cytotoxic T lymphocytes (CTL) and Natural Killer (NK) cells us
 e polarized secretion to destroy virally infected and tumorigenic target c
 ells.  Specialised secretory lysosomes\, containing the pore forming prote
 in perforin and a series of serine proteases\, termed granzymes deliver th
 e lethal hit in a specialized domain of the immunological synapse.  Our re
 search is focused on understanding the molecular basis of polarized secret
 ion from CTL.  We have used a series of rare genetic diseases including He
 rmansky-Pudlak and Haemophagocytic syndromes to identify the roles of prot
 eins involved in secretion from CTL and NK cells.\n\nWe have discovered th
 at CTL and NK cells use a novel secretory mechanism\, with the centrosome 
 polarizing to the precise site of secretion within the immunological synap
 se. Our current research is aimed at understanding the basis of centrosoma
 l localization within the immunological synapse and the mechanisms which d
 etermine secretory lysosome movement\, docking and degranulation.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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