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SUMMARY:From impulsivity to compulsivity: cross-species studies in humans 
 and other animals relevant to neuropsychiatric disorders. - Trevor Robbins
  (Dept of Experimental Psychology)
DTSTART:20100301T160000Z
DTEND:20100301T173000Z
UID:TALK21958@talks.cam.ac.uk
CONTACT:Mandy Carter
DESCRIPTION:This lecture will focus on the utility of the impulsivity and 
 compulsivity constructs for addiction\, attention deficit/hyperactivity di
 sorder (ADHD) and obsessive-compulsive disorder OCD)\, based on analyses o
 f their neuropsychological and neurochemical basis in humans and in other 
 species. Evidence will be reviewed for striatal and prefrontal cortical co
 mponents of these potential neural endophenotypes\, as well as their diffe
 rential chemical modulation by the ascending arousal systems\, including t
 he monoamines and acetylcholine. Evidence will be drawn from studies using
  techniques ranging from functional and structural MR\, positron emission 
 tomography\, selective lesions\, intra-cerebral infusions and systemic psy
 chopharmacology. These methods are used to study performance in tasks meas
 uring different forms of impulsivity\, including the stop-signal task\, as
  well as tests of compulsivity including reversal learning and extra-dimen
 sional set-shifting. The overall theme of the lecture is to illustrate how
  work in basic cognitive and behavioural neuroscience may be translated in
 to the clinical context.\n\nReferences\n\nEveritt BJ\, Robbins TW (2005) N
 eural systems of reinforcement for drug addiction: from actions to habits 
 to compulsion. Nature Neuroscience 8\, 1481-1489\n\nRobbins TW (2007). Shi
 fting and stopping: fronto-striatal substrates\, neurochemical modulation 
 and clinical implications. Philosophical Transactions of The Royal Society
  B\, 362\, 917-932
LOCATION:Department of Experimental Psychology Seminar Room
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