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SUMMARY:LMB Seminar: Metabolism\, Cellular Decisions and the Language That
  Unites Them - Jared Rutter
DTSTART:20241125T110000Z
DTEND:20241125T120000Z
UID:TALK219730@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Mitochondria are dynamic and complex organelles that play a ce
 ntral role in all aspects of biology\, including energy production\, inter
 mediary metabolism\, and apoptosis. These broad cellular functions also pl
 ace mitochondria as a central player in human health and disease.  We have
  focused recently on deciphering the biochemical and cellular functions of
  conserved uncharacterized mitochondrial proteins.  This has revealed new 
 mechanisms for several critical aspects of mitochondrial function\, includ
 ing the Mitochondrial Pyruvate Carrier (MPC)\, which is required for effic
 ient mitochondrial pyruvate uptake.  By perturbing the metabolic program o
 f cells\, MPC manipulation profoundly affects cellular decisions related t
 o stem cell homeostasis and proliferation.  This observation suggests that
  metabolism is not a passive enabler of cell behaviors\, but instead plays
  a decisive role.  One of our current areas of focus\, which will be discu
 ssed\, is to determine the mechanisms whereby metabolism and metabolites a
 ffect behaviors via direct modulation of proteins involved in signaling\, 
 transcription and other regulatory mechanisms.  As we discover these mecha
 nisms\, which we hypothesize to be extensive within biology\, we will be e
 nabled to impinge on such phenomena for therapeutic benefit in disease sta
 tes.
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m\, link:https://mrc-lmb-cam-ac-uk.zoom.us/j/97590440299?pwd=d3k2U3l1WENLb
 llGT1ZUODYyd3lFZz09
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