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SUMMARY:LMB Seminar: Linking nanoscale synapse organization\, function and
  plasticity - Dr Daniel Choquet - University of Bordeux Institute for Inte
 rdisciplinary Neuroscience and the Bordeaux Imaging Center
DTSTART:20240916T100000Z
DTEND:20240916T110000Z
UID:TALK219733@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The spatio-temporal organization of neurotransmitter receptors
  in the postsynaptic membrane is crucial for synaptic transmission and bra
 in information processing. Ionotropic AMPA glutamate receptors (AMPARs) me
 diate fast excitatory synaptic transmission in the CNS. Using high-resolut
 ion single molecule imaging and tracking\, we've found that AMPARs continu
 ously enter and exit the post-synaptic density through lateral diffusion\,
  challenging the belief that they are stable in the synapse. A subset of A
 MPARs clusters into nanodomains\, suggesting that glutamatergic transmissi
 on is regulated at the nanoscale. AMPAR mobility\, influenced by neuronal 
 activity and receptor conformation\, controls both long-term and short-ter
 m synaptic plasticity. We present new experiments on how transmitter relea
 se\, AMPAR desensitization\, and surface diffusion contribute to high-freq
 uency dependent short-term plasticity\, highlighting the role of AMPAR sur
 face diffusion in synaptic potentiation and information processing.
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m\, link:https://mrc-lmb-cam-ac-uk.zoom.us/j/94686992877?pwd=Q0VlRmFsRXNta
 0ZJMVhlRnZqNEs3QT09
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