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SUMMARY:Single neurons in the human medial temporal lobe flexibly shift re
 presentations across spatial and memory tasks - Julie de Falco
DTSTART:20240815T130000Z
DTEND:20240815T140000Z
UID:TALK220024@talks.cam.ac.uk
CONTACT:Adam Triabhall
DESCRIPTION:This week we will discuss and debate a recent paper by Donoghu
 e and colleagues\, published in the Hippocampus (2023).\n\nAbstract: “In
 vestigations into how individual neurons encode behavioral variables of in
 terest have revealed specific representations in single neurons\, such as 
 place and object cells\, as well as a wide range of cells with conjunctive
  encodings or mixed selectivity. However\, as most experiments examine neu
 ral activity within individual tasks\, it is currently unclear if and how 
 neural representations change across different task contexts. Within this 
 discussion\, the medial temporal lobe is particularly salient\, as it is k
 nown to be important for multiple behaviors including spatial navigation a
 nd memory\, however the relationship between these functions is currently 
 unclear. Here\, to investigate how representations in single neurons vary 
 across different task contexts in the medial temporal lobe\, we collected 
 and analyzed single-neuron activity from human participants as they comple
 ted a paired-task session consisting of a passive-viewing visual working m
 emory and a spatial navigation and memory task. Five patients contributed 
 22 paired-task sessions\, which were spike sorted together to allow for th
 e same putative single neurons to be compared between the different tasks.
  Within each task\, we replicated concept-related activations in the worki
 ng memory task\, as well as target-location and serial-position responsive
  cells in the navigation task. When comparing neuronal activity between ta
 sks\, we first established that a significant number of neurons maintained
  the same kind of representation\, responding to stimuli presentations acr
 oss tasks. Further\, we found cells that changed the nature of their repre
 sentation across tasks\, including a significant number of cells that were
  stimulus responsive in the working memory task that responded to serial p
 osition in the spatial task. Overall\, our results support a flexible enco
 ding of multiple\, distinct aspects of different tasks by single neurons i
 n the human medial temporal lobe\, whereby some individual neurons change 
 the nature of their feature coding between task contexts” (Donoghue et a
 l.\, 2023).\n\nReference: Donoghue\, T.\, Cao\, R.\, Han\, C. Z.\, Holman\
 , C. M.\, Brandmeir\, N. J.\, Wang\, S.\, & Jacobs\, J. (2023). Single neu
 rons in the human medial temporal lobe flexibly shift representations acro
 ss spatial and memory tasks. Hippocampus\, 33(5)\, 600–615. https://doi.
 org/10.1002/hipo.23539
LOCATION:https://cam-ac-uk.zoom.us/j/92612577704?pwd=MUtqMjVQdXNmUTVIYjRkM
 G1NUW9GZz09
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