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SUMMARY:Non-apical mitoses contribute to cell delamination during mouse ga
 strulation - Isabelle Migeotte IRIBHM - Jacques E. Dumont Institut Interdi
 sciplinaire en biologie humaine et moléculaire - Université Libre de Bru
 xelles\, Brussels\, BE 
DTSTART:20241015T133000Z
DTEND:20241015T143000Z
UID:TALK220207@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:During the epithelial-mesenchymal transition driving mouse emb
 ryo gastrulation\, cells divide more frequently at the primitive streak\, 
 and half of those divisions happen away from the apical pole. We challenge
 d the molecular determinants of mitosis position in different regions of t
 he epiblast through computational modeling and pharmacological treatments 
 of embryos and stem cell-based epiblast spheroids. Disturbance of the acto
 myosin cytoskeleton or cell cycle dynamics elicits ectopic non-apical mito
 sis and shows that the streak region is characterized by local relaxation 
 of the actomyosin cytoskeleton and less stringent regulation of cell divis
 ion. These factors are essential for normal dynamics at the streak and fav
 or cell delamination from the epiblast.\n\nJoin the Zoom with the link: \n
 https://cam-ac-uk.zoom.us/j/87503254733\nMeeting ID: 875 0325 4733 
LOCATION:online TUESDAY
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