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SUMMARY:Bioengineering neural organoid morphogenesis - Adrian Ranga
DTSTART:20241111T143000Z
DTEND:20241111T153000Z
UID:TALK220219@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Tissues and organs are sculpted by mechanical forces during em
 bryonic development. Organoids provide remarkable in-vitro models to under
 stand how forces lead to developmental complexity by allowing to deconvolv
 e the interactions between differentiation\, patterning\, growth and morph
 ogenesis. However it has been challenging to reproduce the range\, scale a
 nd temporal tissue cytoarchitecture in-vitro. In this talk I will discuss 
 our ongoing efforts in developing customized actuation devices and magneti
 c nanoparticle-based approaches which allow us to spatiotemporally control
  and manipulate mechanical forces\, and how we use these technologies to s
 tudy force-mediated neural patterning and morphogenesis. I will also discu
 ss how we have used a newer model of geometrically constrained neural tube
  morphogenesis to uncover a novel mechanism underlying human neural tube c
 losure. Our work with organoid-based models of neural tube patterning and 
 morphogenesis suggests that the way forward towards engineering reproducib
 le and scalable patterned tissue constructs and understanding mechanisms o
 f neural morphogenesis and may involve harnessing cells’ inherent capaci
 ties for self-organization by providing geometrically and mechanically act
 ive microenvironments.\n\nJoin the Zoom with the link: \nhttps://cam-ac-uk
 .zoom.us/j/87503254733\nMeeting ID: 875 0325 4733
LOCATION:Online
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