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SUMMARY:Chemo-mechanical signal in embryo development - Roberto Mayor
DTSTART:20241118T143000Z
DTEND:20241118T153000Z
UID:TALK220222@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Sir J. Gurdon has claimed that embryonic induction “is proba
 bly the single most important mechanism in vertebrate development\, leadin
 g to differences between cells and the organization of cells into tissues 
 and organs” (1987). Although embryonic induction was discovered over a h
 undred years ago (Spemann and Mangold\, 1924)\, its molecular basis has on
 ly been elucidated in the last three decades with the identification of ma
 ny inducers. However\, this remarkable achievement—identifying the induc
 tive molecules—addresses only half of the problem. Crucially\, embryonic
  induction also requires tissues to be responsive to the inductive signals
  they receive (a concept known as embryonic competence)\; a topic that has
  been widely neglected. Thus far\, researchers have focused on the molecul
 es that may control competence\, while the role of mechanics as a potentia
 l regulator of embryonic competence has remained unexplored. We demonstrat
 ed that the neural crest inductive signal (Wnt) is modulated by the mechan
 otransducer Yes Associated Protein (YAP)\, illustrating how mechanical and
  biochemical cues interplay to control embryonic competence. To demonstrat
 e the universality of our findings\, we showed that the same mechanism ope
 rates in human-induced neural crest cells\, in addition to Xenopus embryos
 . \n\n\nJoin the Zoom with the link: \nhttps://cam-ac-uk.zoom.us/j/8750325
 4733\nMeeting ID: 875 0325 4733
LOCATION:In person at Physiology Lecture Theather\, and online
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