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SUMMARY:Modelling Self-Organisation  - Jeremy Green-King’s College Londo
 n\, London\, United Kingdom
DTSTART:20241125T143000Z
DTEND:20241125T153000Z
UID:TALK220225@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Gastruloids\, which model formation of the primary body axis o
 f vertebrate embryos\, turn themselves from spheres into rods\, breaking s
 ymmetry to organise cell rearrangements known as convergent extension (CE)
 . Gastruloid elongation demonstrates that CE is\, or can be\, entirely sel
 f-organising\, and that self-organising mechanisms are embedded in this\, 
 and likely others of the many instances of CE in development. Classically\
 , self-organisation in biology involves Turing Reaction-Diffusion (RD) pat
 terning by diffusible morphogens. We have explored the possibility that a 
 completely different\, non-RD-based\, self-organisation principle for symm
 etry-breaking by CE could exist\, namely polarity-propagating mechanical f
 eedback\, for which there is experimental evidence at the single-cell leve
 l. Using in silico modelling\, we show that extremely simple rules for mec
 hanical interactions are sufficient to organise convergent extension. Thus
 \, although Turing himself chose to consider only chemical morphogenesis\,
  mechanical self-organisation seems likely to be involved in CE\, either o
 rthogonal to RD or providing a form of “double assurance” (robustness-
 enhancing redundancy).\n\nJoin the Zoom with the link: \nhttps://cam-ac-uk
 .zoom.us/j/87503254733\nMeeting ID: 875 0325 4733 
LOCATION:Online
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