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SUMMARY:Biomolecular Condensates Through a Computational Microscope - Mari
 a Julia Maristany\, University of Cambridge
DTSTART:20241106T143000Z
DTEND:20241106T153000Z
UID:TALK220420@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:One of the greatest current challenges in modern science lies 
 in understanding how life organizes itself at a molecular level. Cells\, c
 omposed of tens of thousands of different proteins\, nucleic acids\, and v
 arious macromolecules\, exhibit behaviors much more complex than the mere 
 sum of their parts. Emergent macroscopic phenomena\, such as phase separat
 ion\, are key mechanisms for cellular viability. Yet\, the physicochemical
  regulators of such phenomena are poorly understood. In this talk\, I want
  to provide a general introduction to exploring how the physicochemical pr
 operties of single molecules can give rise to diverse phase behaviors\, ho
 w these behaviors might impact biological function\, and how we can employ
  coarse-grained molecular dynamic models effectively to probe the differen
 t mechanisms of biomolecular emergent phenomena\, and to design de-novo mo
 lecules with desired bulk properties. To do so\, we will explore several m
 odel systems\, from disordered to ordered proteins\, all the way to chroma
 tin.
LOCATION:Unilever Lecture Theatre\, Yusuf Hamied Department of Chemistry
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