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SUMMARY:21st Armitage Workshop and Lecture - Christopher Jennison\, Univer
 sity of Bath
DTSTART:20241112T092000Z
DTEND:20241112T170000Z
UID:TALK220918@talks.cam.ac.uk
CONTACT:Alison Quenault
DESCRIPTION:In a sequentially designed experiment\, data are evaluated as 
 they are collected and sampling is stopped as soon as the required amount 
 of information is reached or the outcome of a hypothesis test is determine
 d. Formal use of sequential methods dates back to the 1920s and applicatio
 ns of statistical quality control in manufacturing processes. Methods were
  developed further during the second world war with the work of Abraham Wa
 ld in the USA and George Barnard in the UK. Peter Armitage led the way in 
 transferring sequential methods to medical studies and\, after several jou
 rnal articles\, published the book “Sequential Medical Trials” in 1960
 . Key features of medical studies\, as opposed to industrial experiments\,
  are the restriction to a small number of interim analyses and a modest li
 mit on the maximum sample size. These practical requirements led to method
 s based on the precise numerical computations that Peter Armitage and his 
 co-authors presented in the 1960s. In my talk\, I shall survey the many di
 rections in which sequential methods for clinical trials have developed ov
 er the past 60 years. Topics such as optimal design\, response adaptive ra
 ndomisation\, and inference on termination of a sequential trial were alre
 ady studied by Armitage. Other topics\, in particular adaptive designs wit
 h multiple hypothesis testing\, have emerged more recently. Peter Armitage
  made immense contributions to the development of methodology for clinical
  trials: it will be my privilege and my pleasure to describe Peter’s rol
 e in the history of this subject.
LOCATION:Cancer Research UK Cambridge Institute\, Li Ka Shing Centre\, Rob
 inson Way\, Cambridge CB2 0RE
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