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SUMMARY:A V HILL LECTURE  Pain: Why does it exist\, how does it work and h
 ow can we more effectively treat it? - Professor Ewan St John Smith\, Prof
 essor of Nociception\, Deputy Head of Department\, Department of Pharmacol
 ogy
DTSTART:20241111T180000Z
DTEND:20241111T190000Z
UID:TALK221641@talks.cam.ac.uk
CONTACT:Beverley Larner
DESCRIPTION:The sensation of pain is one which nearly everyone is familiar
  with\, usually being considered an unpleasant experience. Wouldn’t a li
 fe without pain be better? Drawing on human genetics and the wider animal 
 kingdom\, we shall see that there are in fact benefits to pain\, or rather
  nociception\, the neural process encoding noxious stimuli. Pain is not ho
 wever static. For example\, following an accident\, the injured part of th
 e body becomes more sensitive\, a phenomenon that usually resolves as the 
 injury heals. Understanding the molecular processes by which pain function
 s and how the sensitivity in the system changes under different conditions
  is important for the development of novel therapeutics to treat the chron
 ic pain\, such as that associated with osteoarthritis\, inflammatory bowel
  disease\, endometriosis\, and a wealth of other conditions. Looking to po
 tential new therapeutic avenues\, we will discuss what can be learned from
  studying human genetics and extremophile organisms\, such as the naked mo
 le-rat\, as well what the future holds regard gene- and cell-based therapy
 .
LOCATION:Bristol-Myers Squibb Lecture Theatre\, Department of Chemistry
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