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SUMMARY:Somatic evolution of the adaptive immune system in health and dise
 ase - Heather Machado (Cambridge Pathology)
DTSTART:20241010T150000Z
DTEND:20241010T160000Z
UID:TALK222097@talks.cam.ac.uk
CONTACT:Michael Boemo
DESCRIPTION:The wealth of somatic mutations that our cells accumulate over
  time provides a valuable resource for understanding how populations of ce
 lls evolve in the context of health and disease. Somatic evolution studies
  of the adaptive immune system can reveal the patterns of immune response 
 and proliferation. One key tool for these studies is phylogenetic lineage 
 tracing\, which can be used to time events in the past. With single-cell w
 hole genome sequencing\, one can build a phylogenetic tree of cells within
  an individual\, read out the age of lymphocyte expansions and identify an
 y mutations of functional consequence. Here\, I will describe two studies 
 where I develop the tools needed for phylogenetic lineage tracing in T cel
 ls. The first performs phylogenetic timing of hematopoeitc stem cells in S
 hwachman-Diamond Syndrome. The second describes the mutational landscape o
 f the adaptive immune system with age. I will then explain how studying th
 e somatic evolution of the adaptive immune response to cancer can be used 
 to address some of most compelling questions in cancer immunology.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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