BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Adding new dimensions to invitro models of stroke and cSVD - Dr Pa
 ul Holloway - University of Oxford
DTSTART:20241024T120000Z
DTEND:20241024T130000Z
UID:TALK222298@talks.cam.ac.uk
CONTACT:Denise Hatherly
DESCRIPTION:Stroke is the largest cause of adult disability in the world a
 nd despite over 1000 prospective neuroprotective agents having been invest
 igated pre-clinically\, none have yet translated to the clinic. A number o
 f key differences in the neurobiology of animal models and humans exist at
  both the cellular and molecular level\, providing impetus to study human 
 based systems. However\, human in vitro stroke models are typically limite
 d to simplistic monolayer cell cultures which fail to recapitulate the hig
 h level of structural organisation in the brain\,  3D heterotypic cellular
  interactions and spatio-temporal localisation of injury. In his lab Dr Ho
 lloway is using a range of techniques from iPSC and organoid cultures to m
 icrofluidic systems\, to model and investigate specific aspects of stroke 
 injury. Dr Holloway’s talk will give an overview of how these different 
 approaches can be used to model neuronal circuits and gliovascular interac
 tions\, along with examples of how these systems can provide novel insight
 s into disease mechanisms and therapeutic opportunities.
LOCATION:VPD-HLRI\, Cambridge Biomedical Campus\, Papworth Road\, Trumping
 ton\, Cambridge CB2 0BB
END:VEVENT
END:VCALENDAR