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SUMMARY:Arabidopsis natural variation: QTL\, genes and 'omics' - Maarten K
 oorneef\, Max Planck Institute for Plant Breeding\, Cologne.
DTSTART:20100128T160000Z
DTEND:20100128T170000Z
UID:TALK22264@talks.cam.ac.uk
CONTACT:Ian Henderson
DESCRIPTION:A large natural genetic variation is present among Arabidopsis
  accessions and is assumed to relate also to the adaptation of the differe
 nt accessions to their natural growth environment. The identification of t
 he allelic variation at the DNA level for the genes contributing to this t
 rait variation\, which is often controlled by several genes\, is a major c
 hallenge. The feasibility to clone individual QTL (Quantitative Trait Loci
 ) by a combination of map based-cloning\, in combination with mutant appro
 aches\, using near-isogenic introgression lines\, has now been demonstrate
 d for several traits. These include flowering time\, seed dormancy\, frost
  tolerance etc. QTL analysis has also been extended to metabolites\, enzym
 e activities\, proteomics and gene expression. This allowed the constructi
 on of molecular genetic networks based on the regulation by the same genes
  (QTL) and may assist the identification of the genes responsible for QTL 
 variation. The use of this approach will be demonstrated on the elucidatio
 n of the genetic regulation of glucosinolates\, flowering and primary meta
 bolism.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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