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SUMMARY:Silencing RNAs are mobile and trigger DNA methylation in distant t
 issue - Attila Molnar
DTSTART:20100108T130000Z
DTEND:20100108T133000Z
UID:TALK22271@talks.cam.ac.uk
CONTACT:15560
DESCRIPTION:RNA silencing in plants has an effect at a distance - cells in
  which silencing is induced by small RNAs produce a signal that moves shor
 t distances through plasmodesmata and long distances through the phloem. T
 he signal elicits nucleotide sequence-specific effects and so it is likely
  to have an RNA component as the specificity determinant. However\, the mo
 bile RNA has not been detected directly and its physical form is not known
 . Genetic evidence is ambiguous because there are multiple pathways of RNA
  silencing in plants with overlapping or interdependent functions. Using h
 igh throughput sequencing of small RNAs in analyses of grafted plants we d
 emonstrated directly that 24 nt small RNAs are mobile. In addition we prov
 ide evidence that endogenous mobile small RNAs can cause changes in DNA me
 thylation at a distance.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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