BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:New mitochondrial mechanisms of degenerative diseases - Professor 
 Anu Suomalainen
DTSTART:20241203T160000Z
DTEND:20241203T170000Z
UID:TALK222718@talks.cam.ac.uk
CONTACT:Lisa Arnold
DESCRIPTION:Mitochondrial diseases show unprecedented variability in diffe
 rent organ manifestations and ages of onset\, but the mechanisms underlyin
 g such spectrum are poorly understood. Here\, we report molecular mechanis
 ms of how exogenous\, actionable factors\, or secondary metabolic pathway 
 imbalance\, have major effects on the disease course\, both for disease on
 set and type of manifestation. For example\, a specific recessively inheri
 ted mitochondrial disease allele in DNA polymerase gamma causes sensitivit
 y to viral infections\, allowing viral replication in early infection and 
 causing a strong delayed proinflammatory response with dramatic effects on
  GABA-ergic neurons and liver homeostasis. Also\, a muscle manifesting mit
 ochondrial disease causes systemic NAD+ deficiency – bodily B3 vitamin d
 eficiency -the rescue of which has functional benefits. Targeting exogenou
 s triggering factors or endogenous secondary metabolic consequences\, base
 d on mechanistic precision targets\, are intriguing intervention strategie
 s\, with potential to delay disease-onset or restore functions. 
LOCATION:The Max Perutz Lecture Theatre\, LMB
END:VEVENT
END:VCALENDAR