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SUMMARY:Directing homeostasis in cells and cell colonies with AI-driven bi
 oelectronics - Professor Marco Rolandi - Department of Electrical and Comp
 uter Engineering University of California\, Santa Cruz
DTSTART:20241017T120000Z
DTEND:20241017T130000Z
UID:TALK222802@talks.cam.ac.uk
CONTACT:Communications\, CEB
DESCRIPTION:"Homeostasis is essential in biological processes and to life 
 itself. To maintain homeostasis receptors and effectors connected in a clo
 sed control loop to achieve and maintain equilibrium. Examples include car
 diac rhythms\, blood glucose regulation\, and thermoregulation. Bioelectro
 nic devices are now able to sense and actuate physiological processes by t
 ranslating biological signals in the form of ions and small molecules into
  electronic signals that can be analysed and processed by information tech
 nologies. I will present our work that merges AI based closed loop control
  with bioelectronic sensors and actuators to direct physiological processe
 s. I will discuss using fluorescent reporters and ion pumps that can chang
 e extracellular ionic concentration to dial membrane potential in stem cel
 ls and bacteria colonies. Membrane potential is a key variable that drives
  cell function and morphogenesis. With this bioelectronic toolbox we can o
 pen up opportunities to direct cell fate and organ shape.  I will also int
 roduce proof-of-concept applications in wound healing."
LOCATION:Lecture Theatre 1\, Department of Chemical Engineering and Biotec
 hnology\, West Cambridge Site
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