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SUMMARY:Disarm and disengage: Understanding Aurodox - a Type III Secretion
  System inhibitor from Streptomyces  - Professor Paul A Hoskisson\, Univer
 sity of Strathclyde\, Glasgow.
DTSTART:20241203T160000Z
DTEND:20241203T170000Z
UID:TALK223117@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Aurodox is an elfamycin-like natural product from the soil bac
 terium Streptomyces goldiniensis\, that can block translation through inhi
 bition of elongation factor (EF-Tu) but has also recently been shown to in
 hibit Type III Secretion Systems. To gain a better understanding of its me
 chanism of action and to assess the utility of this compound as an anti-vi
 rulence molecule we have been using a multidisciplinary approach to unders
 tand the mode of action and biosynthesis of aurodox. Investigating the mod
 e of action of aurodox in Shiga Toxin-producing Escherichia coli (STEC) we
  have shown that it downregulates expression of T3SS\, inhibits epithelial
  colonisation and does not activate the SOS response that results in Shiga
  toxin production. We have also shown that aurodox protects mice from Shig
 a-toxin mediated renal injury and colonic hyperplasia. In parallel we have
  identified and cloned the biosynthetic gene cluster responsible for the b
 iosynthesis of aurodox by Streptomyces goldiniensis\, predicting\, charact
 erising and dissecting its biosynthetic pathway\, opening routes to engine
 ering novel aurodox derivatives. These data suggest that aurodox may repre
 sent a useful candidate therapeutic for the treatment of STEC infections. 
 \n\nBiography Professor Paul A Hoskisson\nPaul Hoskisson is the Royal Acad
 emy of Engineering Research Chair in Engineering biology at the University
  of Strathclyde. Paul completed his first degree at Liverpool John Moores 
 University in 1997 in Applied Microbiology\, before a short period in the 
 industry developing Influenza vaccines. He completed his PhD in 2001\, stu
 dying gentamicin production by the bacterium Micromonospora. Post-doctoral
  work at the John Innes Centre (Norwich) and University of Aberdeen – wo
 rking on various aspects of Streptomyces biology was followed by a move to
  the University of Strathclyde in 2007. The research in Paul’s laborator
 y is focused on evolution of antibiotic biosynthesis\, evolution and domes
 tication of antibiotic producing strains by Streptomyces\, bacteriophage r
 esistance in Streptomyces and antimicrobial resistance. \n\nYou can follow
  Paul on Twitter/X @paulhoskisson\n\n
LOCATION:LT2\, Department of Veterinary Medicine
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