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SUMMARY:“Structure and Mechanisms of LINE-1 retrotransposons: an Emergin
 g Cancer Target” - Marty Taylor\, MD PhD Assistant Professor of Patholog
 y and Laboratory Medicine\, Brown University
DTSTART:20241108T130000Z
DTEND:20241108T140000Z
UID:TALK223489@talks.cam.ac.uk
CONTACT:Ruth Paton
DESCRIPTION:This Cambridge Immunology and Medicine Seminar will take place
  on Friday 8 November 2024\, starting at 1:00pm\, in the Ground Floor Lect
 ure Theatre\, Jeffrey Cheah Biomedical Centre (JCBC)\n\nSpeaker: Dr Marty 
 Taylor\, Assistant Professor of Pathology and Laboratory Medicine\, Brown 
 University\n\nBio: Marty Taylor is a clinician-scientist working to build 
 a molecular understanding of the human LINE-1 transposon (L1) and leverage
  transposon biology into novel strategies for early diagnosis\, prevention
 \, and treatment of cancer and autoimmunity. His recent Nature paper (Natu
 re. 2024 PMID: 38096902) revealed the first structures of the key L1 ORF2 
 reverse transcriptase\, and provided key mechanistic insights into L1 poly
 merization and insertion\, enabling rational drug development. In his new 
 laboratory at Brown University\, his team are dissecting LINE mechanism an
 d pathophysiology\, building a detailed molecular understanding of L1:host
  interactions and their consequences\, and leveraging these insights into 
 novel diagnostics and therapeutics.\n\nTalk Title: “Structure and Mechan
 isms of LINE-1 retrotransposons: an Emerging Cancer Target”\n\nHost: Pau
 l Lehner\, CITIID \, Department of Medicine\n\nRefreshments will be availa
 ble following the Seminar.
LOCATION:Lecture Theatre\, Jeffrey Cheah Biomedical Centre\, Cambridge Bio
 medical Campus
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