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SUMMARY:Species-differences in pathogen recognition and their consequences
  for Vaccines - Professor Dirk Werling\, Dept. of Pathology and Infectious
  Diseases\, Royal Veterinary College
DTSTART:20100217T163000Z
DTEND:20100217T173000Z
UID:TALK22376@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:Toll-Like Receptors (TLRs) are a family of pattern recognition
  receptors that are an\nimportant link between innate and adaptive immunit
 y. Many vaccines incorporate\nligands for TLRs as an adjuvant and are deve
 loped in rodent models\, with the\nresulting data transferred to other spe
 cies. Vaccine features can be improved markedly by emphasising the biologi
 cal relevance when evaluating other animal models for host-pathogen intera
 ction and by taking greater advantage of the unique experimental opportuni
 ties that are\noffered by large animal\, non-rodent models. In the present
  talk\, I will summarise\nour current knowledge of species-specific TLR re
 sponses and briefly discuss that\nvaccine efficacy in relevant host specie
 s might be improved by considering the\nspecies-specific TLR responses.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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