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SUMMARY:What can the olfactory system offer for CNS repair? - Professor Su
 e Barnett\, Professor of Cellular Neurosciences\, Glasgow Biomedical Resea
 rch Centre
DTSTART:20100303T163000Z
DTEND:20100303T173000Z
UID:TALK22378@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:Cell transplantation is one of many possible strategies for en
 couraging regeneration of the injured CNS. The olfactory system\, due to i
 ts inherent regenerative properties\, has been proposed as a candidate tis
 sue for generating cells for transplantation. In fact intact\nolfactory mu
 cosa is being used in clinical trails in several countries for the repair 
 of a range of neurodegenerative disorders. The cellular composition of the
  olfactory system is complex and comprised of many cell types including st
 em cells\, glia and non-neural cells. The relative merits of these various
  cells types to promote CNS repair and induce less of an astrocytic stress
  response in a rat model of spinal cord injury will be discussed. Comparis
 ons will also be made to Schwann cells and their non-neural counterpart is
 olated from the sciatic nerve. Our results suggest that purified glial cel
 ls have advantages over\nnon-neural cells for transplant-mediated repair\,
  combining maximal support for axonal regeneration with a minimal astrocyt
 ic reaction. Lastly a description of an in vitro models of spinal cord wil
 l be shown and data presented on the feasibility of this culture system in
  screening reagents that can affect neurite outgrowth and myelination.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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