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SUMMARY:Exploring an unchartered route across the inner mitochondrial memb
 rane - Dr Thomas MacVicar\, Cancer Research UK Scotland Institute - Univer
 sity of Glasgow
DTSTART:20241127T150000Z
DTEND:20241127T160000Z
UID:TALK223939@talks.cam.ac.uk
CONTACT:Lisa Arnold
DESCRIPTION:Intracellular biochemical reactions are compartmentalised to o
 ptimise energy efficiency and allow cellular adaptation to environment cha
 nges. A staggering variety of metabolites are transported both in and out 
 of mitochondria\, under the exquisite control of dedicated solute carrier 
 proteins. These proteins allow specific molecules to cross the impermeable
  inner mitochondrial membrane and integrate mitochondria in diverse signal
  transduction and metabolic processes. For instance\, mitochondria exchang
 e amino acids for protein and nucleotide biosynthesis and the regulation o
 f oxidative stress responses.\n \nIn this seminar\, I will present our rec
 ent study of mitochondrial methylated amino acid (MeAA) metabolism. MeAAs 
 are obtained from the diet and accumulate within cells upon the degradatio
 n of methylated proteins. Despite the association of disturbed MeAA homeos
 tasis with disorders such as cardiovascular disease and renal failure\, th
 e roles played by mitochondria in MeAA metabolism and signalling are uncle
 ar. I will discuss how mitochondrial MeAA transport is regulated and explo
 re its impact on key metabolic and signalling pathways. Understanding thes
 e will help determine whether mitochondrial uptake and metabolism of MeAAs
  may be future therapeutic targets in cancer and other pathological condit
 ions.
LOCATION:MRC MBU\, Level 3 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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