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SUMMARY:Neurogenesis Under Stress - Dr Alex Gould
DTSTART:20241211T150000Z
DTEND:20241211T160000Z
UID:TALK225316@talks.cam.ac.uk
CONTACT:Lisa Arnold
DESCRIPTION:In the real world\, humans and other animals often develop in 
 environments that are suboptimal for\nmetabolism and growth. In these stre
 ssful contexts\, the growth of key developing organs is prioritized\nat th
 e expense of others\, a process known as organ sparing. It has been clear 
 for many decades that one\nof the most highly spared organs is the brain\,
  and work in our lab has sought to identify the cellular and\nmolecular me
 chanisms responsible. In Drosophila\, we found that the proliferation of n
 eural stem cells\,\nwhich generate all neurons and glia\, is remarkably re
 sistant to a wide range of metabolic stresses\nincluding nutrient restrict
 ion\, hypoxia and oxidative stress. Sparing neural proliferation during st
 ress\ninvolves key interactions between neural stem cells\, their progeny 
 neurons and also glia of the niche\nand blood-brain barrier. Some intercel
 lular interactions required for brain sparing are mediated via\nreceptor t
 yrosine kinase signalling and others via lipid metabolism and transport. I
 n order to understand\nbrain sparing with greater precision\, we are activ
 ely developing new instruments for imaging\nmetabolism at single-cell reso
 lution.
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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