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SUMMARY:“The multifaceted roles of gamma delta T cell subsets in colon c
 ancer”  - Seth B. Coffelt\, Ph.D\, Professor of Cancer Immunology\, Scho
 ol of Cancer Sciences\, University of Glasgow
DTSTART:20250227T160000Z
DTEND:20250227T170000Z
UID:TALK225436@talks.cam.ac.uk
CONTACT:Ruth Paton
DESCRIPTION:This Cambridge Immunology and Medicine Seminar will take place
  on Thursday 27 February 2025\, starting at 4:00pm\, in the Ground Floor L
 ecture Theatre\, Jeffrey Cheah Biomedical Centre (JCBC)\n\nSpeaker: Seth C
 offelt\, Professor of Cancer Immunology\, School of Cancer Sciences\, Univ
 ersity of Glasgow\nCancer Research UK Scotland Institute\n\nTitle: “The 
 multifaceted roles of gamma delta T cell subsets in colon cancer”\n\nAbs
 tract: Understanding how immune cells impact cancer progression and metast
 asis is the major focus of the Coffelt lab. Specifically\, we are interest
 ed in the mechanisms by which gd T cells participate in tumour evolution: 
 from early stages of initiation to late stages of cancer spread. gd T cell
 s encompass several phenotypically and functionally different subsets\, in
 cluding those that traffic between organs and lymph nodes as well as those
  that remain fixed within specific organs. We and others have shown that t
 hese gd T cell subsets can be either tumour-promoting or tumour-opposing. 
 Recently\, we have focused our efforts on gd T cells in colon cancer\, ask
 ing questions about their behaviour during tumour evolution. Using genetic
 ally engineered mouse models of colon cancer\, we have found that gut-resi
 dent Vg7 cells participate in cancer immunosurveillance\, but are excluded
  from the tumour microenvironment. Current efforts are focused on understa
 nding how pro-tumour gd T cells\, including Vg4 and Vg6 cells\, play a rol
 e in tumour initiation. Acquiring this knowledge may help in the design of
  new immunotherapies for patients with colon cancer\n\nHost: Virginia Pedi
 cord\, CITIID\, Cambridge\n\nRefreshments will be available following the 
 seminar.
LOCATION: Lecture Theatre\, Jeffrey Cheah Biomedical Centre\, Cambridge Bi
 omedical Campus
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