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SUMMARY:Morphogenetic control of cellular differentiation during gastrulat
 ion  - Marta Shahbazi\, MRC Laboratory of Molecular Biology\, Cambridge\, 
 UK
DTSTART:20250127T143000Z
DTEND:20250127T153000Z
UID:TALK225499@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Embryo development entails the generation of diverse cellular 
 identities and tissues morphologies. Cells need to take the right decision
 \, at the right location\, at the right time\, and this decision needs to 
 be coordinated with concurrent changes in tissue organisation. The mechani
 sms that ensure the tight coordination between cell fate decisions and tis
 sue shape changes remain poorly explored. To address this question\, my gr
 oup focuses on the development of the mammalian embryo at the time of impl
 antation into the uterus\, a developmental stage that involves a global tr
 anscriptional and morphological transformation. Using embryo culture metho
 ds and 3D stem cell models\, we have recently uncovered novel functional c
 onnections between the loss of epithelial architecture and the differentia
 tion of pluripotent cells at gastrulation. 
LOCATION:in person at Hodgkin-Huxley Seminar Room\, PDN and online
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