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SUMMARY:Fundamental principles during the egg-to-embryo transition - Andre
 a Pauli\, IMP (Institute of Molecular Pathology)\, Vienna\, Austria
DTSTART:20250203T143000Z
DTEND:20250203T153000Z
UID:TALK225502@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Life of sexually reproducing organisms starts with the fusion 
 of two highly specialized cells\, the egg and the sperm\, which gives rise
  to a single cell\, the zygote. Fertilization initiates the egg-to-embryo 
 transition\, one of the most dramatic developmental transition resulting i
 n the transformation of the egg from a dormant state into regulatorily and
  functionally distinct embryonic cells. While this transition has been stu
 died extensively in respect to zygotic genome activation\, the molecular m
 echanisms that mediate sperm-egg binding and fusion during fertilization a
 nd regulate the maintenance of dormancy in the egg and re-activation in th
 e embryo remain poorly understood. The vision of the Pauli lab is to gain 
 mechanistic insights into the egg-to-embryo transition\, with a specific f
 ocus on the molecular control of fertilization and developmentally program
 med dormancy and re-activation.   \n\nAndrea (Andi) Pauli will talk about 
 recent findings from her lab related to their work towards uncovering the 
 mechanism of vertebrate fertilization and translational regulation during 
 the egg-to-embryo transition. By combining genetic\, molecular\, cellular\
 , biochemical\, structural and genomics approaches in their main model org
 anism\, the zebrafish\, the long-term vision of the Pauli lab is to unrave
 l new concepts and molecular mechanisms governing this fascinating develop
 mental transition that marks the beginning of life.
LOCATION:Online
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