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SUMMARY:LMB Seminar - One or two membranes? Investigating the transition b
 etween monoderm and diderm cell envelopes across the Tree of Bacteria - IN
  PERSON ONLY - Simonetta Gribaldo\, Intstitut Pasteur
DTSTART:20250310T110000Z
DTEND:20250310T120000Z
UID:TALK225706@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The cell envelope is one of the oldest and most fundamental bi
 ological structures\, and a major target of antimicrobials. Bacteria can h
 ave radically different envelopes\, containing either one (monoderm) or tw
 o (diderm) membranes\, generally known as Gram-positives and Gram-negative
 s. How and why such dramatic transition occurred has remained a major open
  question in evolutionary biology. In my talk\, I will present recent data
  where we addressed this issue by merging large-scale computational analys
 es with experimental evolution using a new bacterial model at the interfac
 e between diderms and monoderms. Our results challenge established paradig
 ms and propose a hypothesis on how the monoderm/diderm transition might ha
 ve occurred.
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) 
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