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SUMMARY:The Francis Crick Lecture 2025 - The DNA Quadruplex Helix - Shanka
 r Balasubramaniam\, University of Cambridge
DTSTART:20250219T110000Z
DTEND:20250219T120000Z
UID:TALK225709@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:While DNA has been thought to exist primarily as a two-strande
 d double helix\, there are alternative structures that can form. Particula
 r G-rich sequences can fold into four-stranded structures called G-quadrup
 lexes under physiological conditions. In this lecture\, I will present our
  studies to explore the existence and function of G-quadruplexes structure
 s in the DNA of cells and tissues in humans and in other species. The data
  suggests G-quadruplexes can play important roles in controlling transcrip
 tion and cellular identity. Chemical biology approaches have been vital to
  help elucidate G-quadruplexes and provide insights into pathways for inte
 rvention that hold potential for therapeutics.
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m link https://mrc-lmb-cam-ac-uk.zoom.us/j/93702571246?pwd=I6zsi0w8N5XcKg2
 gu0bac58rcyTfba.1
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