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SUMMARY:LMB Seminar - Higher Order Transient structures and the principle 
 of dynamic connectivity in membrane signaling - Rod MacKinnon - Rockefelle
 r University
DTSTART:20250407T100000Z
DTEND:20250407T110000Z
UID:TALK225715@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Cells convey signals (information) across their membranes thro
 ugh the interactions of membrane proteins that communicate with each other
 \, forming what are called signal pathways\, which are analogous to the co
 nnected components in an electronic circuit. But cell membranes are 2-dime
 nsional liquids in which diffusion dominates\, raising the questions how d
 o the components connect\, and why do coexisting pathways\, which often sh
 are components\, not interfere with each other? In this presentation I wil
 l show you that many membrane proteins assemble into weakly-interacting\, 
 transient\, molecular-specific clusters of self\, which we call higher ord
 er transient structures (HOTS). Because molecular specificity invokes self
 -recognition through protein sequence and structure\, we propose that HOTS
  are genetically encoded macromolecular units. I will explain how HOTS can
  (1) underlie a dynamic connectivity by tying together in a statistical ma
 nner the components of a signal pathway and (2) permit multiple signal pat
 hways to coexist in the cell membrane\, functioning without interference. 
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m link https://mrc-lmb-cam-ac-uk.zoom.us/j/92311841585?pwd=auhAdp8eTD8Ca0x
 GZpaNlZrChEcHAr.1
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